Mallary Darby took the ball into the circle for the Wolf Pack, going 3.2 innings, giving up five hits and one earned run in the loss.
The Broncos got their first run on two Nevada errors in the first, but Darby was able to hold them to no more, getting out of the top of the first without any further damage.
A pitchers dual through the first three and a half, the game was decided in a fourth inning that saw Boise State score 12 runs, 11 of them unearned.
Offensively, Nevada ended the day with four hits, and had chances to push runs across, including the fourth and fifth innings.
In the fourth, Britton Murdock stole second with two outs, but was stranded there when Megan Fincher hit a hard ground ball right at the Broncos third baseman Kelly Sweeny.
Boise State responded to the Pack's first threat of the afternoon in the top of the fourth by getting 12 in the bottom of the frame including a two-run home run to left field by Devon Bridges. The first batter of the frame, Allie Crump, reached on an error.
Boise State capitalized on that error, and Nevada's two others in the game, as all but one of their 13 runs was unearned.
The Pack put two runners on in the fifth, ending the inning with another hard ground ball to third.
Games two of the series will be played beginning noon Pacific time Saturday, with game three played immediately after, in a doubleheader format.